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Smarcc2 Gene Detail
Summary
  • Symbol
    Smarcc2
  • Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
  • Synonyms
    5930405J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915344
    NCBI Gene: 68094
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128295117-128326351 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915344
 protein coding gene Chr10:128294823-128326460 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017866
 protein coding gene Chr10:132200819-132234015 (+)
A/J MGP_AJ_G0017841
 protein coding gene Chr10:126887502-126918764 (+)
AKR/J MGP_AKRJ_G0017804
 protein coding gene Chr10:130609130-130640547 (+)
BALB/cJ MGP_BALBcJ_G0017805
 protein coding gene Chr10:127270650-127302308 (+)
C3H/HeJ MGP_C3HHeJ_G0017628
 protein coding gene Chr10:130772795-130803931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018260
 protein coding gene Chr10:136675053-136709756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015938
 protein coding gene Chr10:120819694-120851662 (+)
CAST/EiJ MGP_CASTEiJ_G0017189
 protein coding gene Chr10:131485306-131520024 (+)
CBA/J MGP_CBAJ_G0017598
 protein coding gene Chr10:142226293-142275858 (+)
DBA/2J MGP_DBA2J_G0017704
 protein coding gene Chr10:125951678-125985778 (+)
FVB/NJ MGP_FVBNJ_G0017699
 protein coding gene Chr10:124876470-124907660 (+)
LP/J MGP_LPJ_G0017778
 protein coding gene Chr10:132788213-132821963 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017727
 protein coding gene Chr10:144825262-144859335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018300
 protein coding gene Chr10:130716072-130748915 (+)
PWK/PhJ MGP_PWKPhJ_G0016974
 protein coding gene Chr10:126208700-126241989 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016763
 protein coding gene Chr10:129812504-129847331 (+)
WSB/EiJ MGP_WSBEiJ_G0017248
 protein coding gene Chr10:130928567-130962135 (+)



Homology
more
  • Human Ortholog
    SMARCC2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMARCC2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  • Synonyms
    BAF170, CRACC2, CSS8, Rsc8
  • Links
    NCBI Gene ID: 6601
    neXtProt AC: NX_Q8TAQ2
    UniProt: Q8TAQ2

  • Chr Location
    12q13.2; chr12:56162359-56189567 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SMARCC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit a slight increase in embryo weight at E13.5 and die shortly after birth (P0-P3). Mice homozygous for a conditional allele activated in the brain exhibit reduced cerebral cortical size and thickness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    43
  • cDNA Data
    212
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025369 Ensembl Gene Model | MGI Sequence Detail 31235 C57BL/6J ±  kb
    transcript ENSMUST00000105235 Ensembl | MGI Sequence Detail 4032 Not Applicable  
    polypeptide ENSMUSP00000100868 Ensembl | MGI Sequence Detail 1213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 213
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 31
      Gene Ontology 31
      Phenotypes 20
    • Earliest
      J:320308 Valka I, et al., Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. Planta Med. 1985 Aug;51(4):319-22
    • Latest
      J:342013 Ramachandran J, et al., The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds. Dev Biol. 2023 Oct 5;504:128-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory