About   Help   FAQ
Ddx59 Gene Detail
Summary
  • Symbol
    Ddx59
  • Name
    DEAD box helicase 59
  • Synonyms
    1210002B07Rik, 4833411G06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915247
    NCBI Gene: 67997
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136343009-136367896 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.73 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915247
protein coding gene Chr1:136343009-136384019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016541
protein coding gene Chr1:140245635-140271613 (+)
A/J MGP_AJ_G0016524
protein coding gene Chr1:134923416-134948695 (+)
AKR/J MGP_AKRJ_G0016489
protein coding gene Chr1:138931302-138957323 (+)
BALB/cJ MGP_BALBcJ_G0016484
protein coding gene Chr1:135253989-135279407 (+)
C3H/HeJ MGP_C3HHeJ_G0016310
protein coding gene Chr1:139031492-139063976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016945
protein coding gene Chr1:145257754-145283235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014656
protein coding gene Chr1:128036516-128063764 (+)
CAST/EiJ MGP_CASTEiJ_G0015890
protein coding gene Chr1:138131424-138163285 (+)
CBA/J MGP_CBAJ_G0016283
protein coding gene Chr1:150295530-150320412 (+)
DBA/2J MGP_DBA2J_G0016389
protein coding gene Chr1:133916279-133941183 (+)
FVB/NJ MGP_FVBNJ_G0016388
protein coding gene Chr1:132566268-132591104 (+)
LP/J MGP_LPJ_G0016460
protein coding gene Chr1:141449620-141482079 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016413
protein coding gene Chr1:155923427-155951043 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016981
protein coding gene Chr1:138699177-138725889 (+)
PWK/PhJ MGP_PWKPhJ_G0015676
protein coding gene Chr1:132969096-132995227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015463
protein coding gene Chr1:137689576-137718047 (+)
WSB/EiJ MGP_WSBEiJ_G0015953
protein coding gene Chr1:138741765-138766613 (+)



Homology
more
  • Human Ortholog
    DDX59, DEAD-box helicase 59
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX59, DEAD-box helicase 59
  • Synonyms
    OFD5, ZNHIT5
  • Links
    NCBI Gene ID: 83479
    neXtProt AC: NX_Q5T1V6
    UniProt: Q5T1V6

  • Chr Location
    1q32.1; chr1:200623896-200669907 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DDX59 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026404 Ensembl Gene Model | MGI Sequence Detail 24888 C57BL/6J ±  kb
    transcript ENSMUST00000027655 Ensembl | MGI Sequence Detail 2166 Not Applicable  
    polypeptide ENSMUSP00000027655 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1918884
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:206678 Shamseldin HE, et al., Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. Am J Hum Genet. 2013 Sep 5;93(3):555-60

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory