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Tmem100 Gene Detail
Summary
  • Symbol
    Tmem100
  • Name
    transmembrane protein 100
  • Synonyms
    1810057C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915138
    NCBI Gene: 67888
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:89921174-89927334 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 54.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915138
 protein coding gene Chr11:89921174-89927334 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018936
 protein coding gene Chr11:91829403-91838122 (+)
A/J MGP_AJ_G0018904
 protein coding gene Chr11:88238767-88244946 (+)
AKR/J MGP_AKRJ_G0018874
 protein coding gene Chr11:90956801-90962978 (+)
BALB/cJ MGP_BALBcJ_G0018877
 protein coding gene Chr11:88691547-88697728 (+)
C3H/HeJ MGP_C3HHeJ_G0018691
 protein coding gene Chr11:90978880-90985032 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019329
 protein coding gene Chr11:94713260-94719404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016960
 protein coding gene Chr11:85279871-85286022 (+)
CAST/EiJ MGP_CASTEiJ_G0018246
 protein coding gene Chr11:91720495-91740887 (+)
CBA/J MGP_CBAJ_G0018662
 protein coding gene Chr11:98662432-98668592 (+)
DBA/2J MGP_DBA2J_G0018770
 protein coding gene Chr11:87794685-87800848 (+)
FVB/NJ MGP_FVBNJ_G0018759
 protein coding gene Chr11:87308623-87314799 (+)
LP/J MGP_LPJ_G0018840
 protein coding gene Chr11:92342756-92348938 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018786
 protein coding gene Chr11:98538905-98546675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019369
 protein coding gene Chr11:91202623-91208804 (+)
PWK/PhJ MGP_PWKPhJ_G0018016
 protein coding gene Chr11:88690168-88711240 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017806
 protein coding gene Chr11:90770763-90776920 (+)
WSB/EiJ MGP_WSBEiJ_G0018295
 protein coding gene Chr11:91069648-91077323 (+)



Homology
more
  • Human Ortholog
    TMEM100, transmembrane protein 100
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM100, transmembrane protein 100
  • Links
    NCBI Gene ID: 55273
    neXtProt AC: NX_Q9NV29
    UniProt: Q9NV29

  • Chr Location
    17q22; chr17:55719627-55732121 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 5 genetic backgrounds
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutations display prenatal lethality. Mice homozygous for one null mutation display defects in arterial differentiation and maturation and complete lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1139
  • Tissues
    227
  • cDNA Data
    18
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67888 NCBI Gene Model | MGI Sequence Detail 6161 C57BL/6J ±  kb
    transcript NM_026433 RefSeq | MGI Sequence Detail 1764 C57BL/6  
    polypeptide Q9CQG9 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144451
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:334917 Nees TA, et al., Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nat Commun. 2023 Apr 5;14(1):1899
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory