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Dgat2 Gene Detail
Summary
  • Symbol
    Dgat2
  • Name
    diacylglycerol O-acyltransferase 2
  • Synonyms
    0610010B06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915050
    NCBI Gene: 67800
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:98802870-98831920 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.01 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915050
protein coding gene Chr7:98802865-98831926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032545
protein coding gene Chr7:101926255-101956614 (-)
A/J MGP_AJ_G0032519
protein coding gene Chr7:99398252-99426945 (-)
AKR/J MGP_AKRJ_G0032455
protein coding gene Chr7:101758919-101789032 (-)
BALB/cJ MGP_BALBcJ_G0032530
protein coding gene Chr7:99087312-99116398 (-)
C3H/HeJ MGP_C3HHeJ_G0032245
protein coding gene Chr7:102115371-102144047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033028
protein coding gene Chr7:105847849-105876501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030023
protein coding gene Chr7:101835929-101864869 (-)
CAST/EiJ MGP_CASTEiJ_G0031572
protein coding gene Chr7:93651657-93681538 (-)
CBA/J MGP_CBAJ_G0032212
protein coding gene Chr7:109473823-109502494 (-)
DBA/2J MGP_DBA2J_G0032364
protein coding gene Chr7:97738424-97767109 (-)
FVB/NJ MGP_FVBNJ_G0032321
protein coding gene Chr7:97528648-97558139 (-)
LP/J MGP_LPJ_G0032453
protein coding gene Chr7:103248552-103285177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032353
protein coding gene Chr7:110946384-110976902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033050
protein coding gene Chr7:101027939-101057502 (-)
PWK/PhJ MGP_PWKPhJ_G0031290
protein coding gene Chr7:90825440-90854872 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031133
protein coding gene Chr7:88325618-88355530 (-)
WSB/EiJ MGP_WSBEiJ_G0031689
protein coding gene Chr7:101699250-101727867 (-)



Homology
more
  • Human Ortholog
    DGAT2, diacylglycerol O-acyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGAT2, diacylglycerol O-acyltransferase 2
  • Synonyms
    ARAT, GS1999FULL, HMFN1045
  • Links
    NCBI Gene ID: 84649
    neXtProt AC: NX_Q96PD7
    UniProt: Q96PD7

  • Chr Location
    11q13.5; chr11:75759512-75801535 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DGAT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die shortly after birth due to inadequate substrates for energy and impaired skin barrier function leading to dehydration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67800 NCBI Gene Model | MGI Sequence Detail 29051 C57BL/6J ±  kb
    transcript NM_026384 RefSeq | MGI Sequence Detail 2251 C57BL/6  
    polypeptide Q9DCV3 UniProt | EBI | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 6
      Primer pair 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 15
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:340032 Paredes A, et al., gamma-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023 Jun;618(7964):365-373

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory