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N6amt1 Gene Detail
Summary
  • Symbol
    N6amt1
  • Name
    N-6 adenine-specific DNA methyltransferase 1 (putative)
  • Synonyms
    5830445C04Rik, Hemk2, Pred28
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915018
    NCBI Gene: 67768
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87151073-87165537 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.52 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915018
 protein coding gene Chr16:87151073-87165630 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022975
 protein coding gene Chr16:88065882-88080333 (+)
A/J MGP_AJ_G0022943
 protein coding gene Chr16:84009841-84023040 (+)
AKR/J MGP_AKRJ_G0022913
 protein coding gene Chr16:86554068-86567311 (+)
BALB/cJ MGP_BALBcJ_G0022945
 protein coding gene Chr16:84526057-84548314 (+)
C3H/HeJ MGP_C3HHeJ_G0022707
 protein coding gene Chr16:87118988-87132932 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023392
 protein coding gene Chr16:90922749-90940656 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020896
 protein coding gene Chr16:81864896-81877433 (+)
CAST/EiJ MGP_CASTEiJ_G0022229
 protein coding gene Chr16:87501037-87516351 (+)
CBA/J MGP_CBAJ_G0022676
 protein coding gene Chr16:94819019-94842574 (+)
DBA/2J MGP_DBA2J_G0022810
 protein coding gene Chr16:83931536-83946367 (+)
FVB/NJ MGP_FVBNJ_G0022785
 protein coding gene Chr16:83035383-83048323 (+)
LP/J MGP_LPJ_G0022879
 protein coding gene Chr16:87758320-87772325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022804
 protein coding gene Chr16:99383310-99399866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023410
 protein coding gene Chr16:87020242-87034506 (+)
PWK/PhJ MGP_PWKPhJ_G0021971
 protein coding gene Chr16:84035297-84048191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021802
 protein coding gene Chr16:86553141-86568067 (+)
WSB/EiJ MGP_WSBEiJ_G0022277
 protein coding gene Chr16:87263156-87278411 (+)



Homology
more
  • Human Ortholog
    N6AMT1, N-6 adenine-specific DNA methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    N6AMT1, N-6 adenine-specific DNA methyltransferase 1
  • Synonyms
    C21orf127, HEMK2, KMT9, m.HsaHemK2P, MTQ2, N6AMT, PRED28, PrmC
  • Links
    NCBI Gene ID: 29104
    neXtProt AC: NX_Q9Y5N5
    UniProt: Q9Y5N5

  • Chr Location
    21q21.3; chr21:28575598-28885371 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to form a primitive streak and die between E7.5 and E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    65
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67768 NCBI Gene Model | MGI Sequence Detail 14465 C57BL/6J ±  kb
    transcript NM_026366 RefSeq | MGI Sequence Detail 1791 Not Specified  
    polypeptide Q6SKR2 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory