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Nsmce1 Gene Detail
Summary
  • Symbol
    Nsmce1
  • Name
    NSE1 homolog, SMC5-SMC6 complex component
  • Synonyms
    2510027N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914961
    NCBI Gene: 67711
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125066816-125090615 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.87 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    382 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914961
 protein coding gene Chr7:125066812-125090768 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032967
 protein coding gene Chr7:129678712-129703438 (-)
A/J MGP_AJ_G0032950
 protein coding gene Chr7:126282300-126306242 (-)
AKR/J MGP_AKRJ_G0032882
 protein coding gene Chr7:129481203-129505258 (-)
BALB/cJ MGP_BALBcJ_G0032955
 protein coding gene Chr7:125934377-125958417 (-)
C3H/HeJ MGP_C3HHeJ_G0032665
 protein coding gene Chr7:129394322-129418278 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033461
 protein coding gene Chr7:134757593-134784969 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030433
 protein coding gene Chr7:127486297-127511602 (-)
CAST/EiJ MGP_CASTEiJ_G0031993
 protein coding gene Chr7:121180204-121207092 (-)
CBA/J MGP_CBAJ_G0032638
 protein coding gene Chr7:139274336-139298331 (-)
DBA/2J MGP_DBA2J_G0032790
 protein coding gene Chr7:124256084-124281209 (-)
FVB/NJ MGP_FVBNJ_G0032743
 protein coding gene Chr7:124093187-124117121 (-)
LP/J MGP_LPJ_G0032884
 protein coding gene Chr7:131140433-131167359 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032775
 protein coding gene Chr7:140525130-140549510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033481
 protein coding gene Chr7:128471314-128495300 (-)
PWK/PhJ MGP_PWKPhJ_G0031701
 protein coding gene Chr7:117234848-117259019 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031547
 protein coding gene Chr7:115301893-115326072 (-)
WSB/EiJ MGP_WSBEiJ_G0032106
 protein coding gene Chr7:129445664-129470588 (-)



Homology
more
  • Human Ortholog
    NSMCE1, NSE1 homolog, SMC5-SMC6 complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSMCE1, NSE1 homolog, SMC5-SMC6 complex component
  • Synonyms
    NSE1
  • Links
    NCBI Gene ID: 197370
    neXtProt AC: NX_Q8WV22
    UniProt: Q8WV22

  • Chr Location
    16p12.1; chr16:27224994-27268772 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    84
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67711 NCBI Gene Model | MGI Sequence Detail 23800 C57BL/6J ±  kb
    transcript NM_001377012 RefSeq | MGI Sequence Detail 1579 C57BL/6  
    polypeptide Q9D720 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011447 non-structural maintenance of chromosomes element 1
      (term hierarchy)
    • EC
      2.3.2.27
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR011513 Non-structural maintenance of chromosomes element 1
      IPR014857 Non-structural maintenance of chromosomes element 1, RING C4HC3-type
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR036388 Winged helix-like DNA-binding domain superfamily
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 84

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory