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Tmco5 Gene Detail
Summary
  • Symbol
    Tmco5
  • Name
    transmembrane and coiled-coil domains 5
  • Synonyms
    1700095F04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914606
    NCBI Gene: 67356
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:116709172-116722975 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.03 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914606
 protein coding gene Chr2:116709172-116722987 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026307
 protein coding gene Chr2:119480304-119494045 (+)
A/J MGP_AJ_G0026268
 protein coding gene Chr2:114633166-114646967 (+)
AKR/J MGP_AKRJ_G0026247
 protein coding gene Chr2:117830922-117844693 (+)
BALB/cJ MGP_BALBcJ_G0026281
 protein coding gene Chr2:114881563-114895270 (+)
C3H/HeJ MGP_C3HHeJ_G0026026
 protein coding gene Chr2:118265932-118281896 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026728
 protein coding gene Chr2:123418261-123432016 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024108
 protein coding gene Chr2:109712076-109725891 (+)
CAST/EiJ MGP_CASTEiJ_G0025489
 protein coding gene Chr2:118579493-118593270 (+)
CBA/J MGP_CBAJ_G0026003
 protein coding gene Chr2:127772376-127786121 (+)
DBA/2J MGP_DBA2J_G0026142
 protein coding gene Chr2:114063791-114079448 (+)
FVB/NJ MGP_FVBNJ_G0026104
 protein coding gene Chr2:112895224-112908969 (+)
LP/J MGP_LPJ_G0026243
 protein coding gene Chr2:119813137-119826898 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026123
 protein coding gene Chr2:132194242-132208001 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026783
 protein coding gene Chr2:117938113-117951866 (+)
PWK/PhJ MGP_PWKPhJ_G0025225
 protein coding gene Chr2:113609134-113623176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025024
 protein coding gene Chr2:117073448-117087766 (+)
WSB/EiJ MGP_WSBEiJ_G0025558
 protein coding gene Chr2:118768242-118781995 (+)



Homology
more
  • Human Ortholog
    TMCO5A, transmembrane and coiled-coil domains 5A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMCO5A, transmembrane and coiled-coil domains 5A
  • Synonyms
    TMCO5
  • Links
    NCBI Gene ID: 145942
    neXtProt AC: NX_Q8N6Q1
    UniProt: Q8N6Q1

  • Chr Location
    15q14; chr15:37921939-38040865 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Male mice homozygous for a mutation are viable and show normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027355 Ensembl Gene Model | MGI Sequence Detail 13804 C57BL/6J ±  kb
transcript ENSMUST00000028834 Ensembl | MGI Sequence Detail 1164 Not Applicable  
polypeptide ENSMUSP00000028834 Ensembl | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031670 transmembrane and coiled-coil domain-containing protein 5A
    (term hierarchy)
  • InterPro Domains
    IPR026617 Transmembrane and coiled-coil domain-containing protein 2/5
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:301699 Yamase K, et al., Mouse TMCO5 is localized to the manchette microtubules involved in vesicle transfer in the elongating spermatids. PLoS One. 2019;14(8):e0220917
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory