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Ndufb8 Gene Detail
Summary
  • Symbol
    Ndufb8
  • Name
    NADH:ubiquinone oxidoreductase subunit B8
  • Synonyms
    2900010I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914514
    NCBI Gene: 67264
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:44537011-44543879 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 37.98 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914514
 protein coding gene Chr19:44537010-44543881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025174
 protein coding gene Chr19:44048541-44055409 (-)
A/J MGP_AJ_G0025151
 protein coding gene Chr19:41939275-41946143 (-)
AKR/J MGP_AKRJ_G0025119
 protein coding gene Chr19:43288334-43295202 (-)
BALB/cJ MGP_BALBcJ_G0025145
 protein coding gene Chr19:41989289-41996157 (-)
C3H/HeJ MGP_C3HHeJ_G0024905
 protein coding gene Chr19:43442669-43449537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025588
 protein coding gene Chr19:45132370-45139238 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023002
 protein coding gene Chr19:41210937-41218037 (-)
CAST/EiJ MGP_CASTEiJ_G0024370
 protein coding gene Chr19:43168954-43175831 (-)
CBA/J MGP_CBAJ_G0024885
 protein coding gene Chr19:47404016-47410884 (-)
DBA/2J MGP_DBA2J_G0025017
 protein coding gene Chr19:41757059-41763927 (-)
FVB/NJ MGP_FVBNJ_G0024978
 protein coding gene Chr19:41527982-41534850 (-)
LP/J MGP_LPJ_G0025103
 protein coding gene Chr19:43985438-43992306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025009
 protein coding gene Chr19:46839815-46846683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025646
 protein coding gene Chr19:43359622-43366505 (-)
PWK/PhJ MGP_PWKPhJ_G0024119
 protein coding gene Chr19:41656255-41663133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023923
 protein coding gene Chr19:42048404-42055264 (-)
WSB/EiJ MGP_WSBEiJ_G0024440
 protein coding gene Chr19:43487385-43494253 (-)



Homology
more
  • Human Ortholog
    NDUFB8, NADH:ubiquinone oxidoreductase subunit B8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFB8, NADH:ubiquinone oxidoreductase subunit B8
  • Synonyms
    ASHI, CI-ASHI, MC1DN32
  • Links
    NCBI Gene ID: 4714
    neXtProt AC: NX_O95169
    UniProt: O95169

  • Chr Location
    10q24.31; chr10:100523729-100530000 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal trophoblast layer formation and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    12
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    107
  • cDNA Data
    245
  • Literature Summary
    26
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025204 Ensembl Gene Model | MGI Sequence Detail 6869 C57BL/6J ±  kb
transcript ENSMUST00000026222 Ensembl | MGI Sequence Detail 680 Not Applicable  
polypeptide ENSMUSP00000026222 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 247
    cDNA 245
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147623
References
more
  • Summaries
    All 69
    Developmental Gene Expression 26
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:346373 Liu B, et al., NPC1 is required for postnatal islet beta cell differentiation by maintaining mitochondria turnover. Theranostics. 2024;14(5):2058-2074
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory