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Mettl21a Gene Detail
Summary
  • Symbol
    Mettl21a
  • Name
    methyltransferase 21A, HSPA lysine
  • Synonyms
    2310038H17Rik, Fam119a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914349
    NCBI Gene: 67099
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:64645632-64656401 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914349
 protein coding gene Chr1:64645632-64661926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016096
 protein coding gene Chr1:64783744-64794538 (-)
A/J MGP_AJ_G0016079
 protein coding gene Chr1:62501757-62512549 (-)
AKR/J MGP_AKRJ_G0016036
 protein coding gene Chr1:64249325-64260111 (-)
BALB/cJ MGP_BALBcJ_G0016034
 protein coding gene Chr1:62596388-62607157 (-)
C3H/HeJ MGP_C3HHeJ_G0015866
 protein coding gene Chr1:64528284-64539078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016487
 protein coding gene Chr1:67290816-67302921 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014208
 protein coding gene Chr1:58556959-58568070 (-)
CAST/EiJ MGP_CASTEiJ_G0015449
 protein coding gene Chr1:63790977-63800700 (-)
CBA/J MGP_CBAJ_G0015838
 protein coding gene Chr1:69480082-69491882 (-)
DBA/2J MGP_DBA2J_G0015939
 protein coding gene Chr1:61907200-61917991 (-)
FVB/NJ MGP_FVBNJ_G0015942
 protein coding gene Chr1:61184973-61195649 (-)
LP/J MGP_LPJ_G0016011
 protein coding gene Chr1:65686690-65697484 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015962
 protein coding gene Chr1:72345261-72356784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016534
 protein coding gene Chr1:64232795-64244885 (-)
PWK/PhJ MGP_PWKPhJ_G0015236
 protein coding gene Chr1:61290351-61301475 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015015
 protein coding gene Chr1:63722327-63734725 (-)
WSB/EiJ MGP_WSBEiJ_G0015511
 protein coding gene Chr1:63940031-63950806 (-)



Homology
more
  • Human Ortholog
    METTL21A, methyltransferase 21A, HSPA lysine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL21A, methyltransferase 21A, HSPA lysine
  • Synonyms
    FAM119A, HCA557b, HSPA-KMT
  • Links
    NCBI Gene ID: 151194
    neXtProt AC: NX_Q8WXB1
    UniProt: Q8WXB1

  • Chr Location
    2q33.3; chr2:207580631-207626053 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Mettl21a
  • Find Mice (IMSR)
    18 strains or lines available
Mice homozygous for a null allele exhibit normal male fertility and spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    30
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025956 Ensembl Gene Model | MGI Sequence Detail 10770 C57BL/6J ±  kb
transcript ENSMUST00000053469 Ensembl | MGI Sequence Detail 2666 Not Applicable  
polypeptide ENSMUSP00000050424 Ensembl | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 6
Other
Accession IDs
less
MGI:2138265
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory