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Gatm Gene Detail
Summary
  • Symbol
    Gatm
  • Name
    glycine amidinotransferase (L-arginine:glycine amidinotransferase)
  • Synonyms
    1810003P21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914342
    NCBI Gene: 67092
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122424954-122441758 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914342
 protein coding gene Chr2:122424948-122441784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026417
 protein coding gene Chr2:125624833-125641413 (-)
A/J MGP_AJ_G0026379
 protein coding gene Chr2:120489780-120506376 (-)
AKR/J MGP_AKRJ_G0026355
 protein coding gene Chr2:123937740-123956080 (-)
BALB/cJ MGP_BALBcJ_G0026391
 protein coding gene Chr2:120771435-120789895 (-)
C3H/HeJ MGP_C3HHeJ_G0026135
 protein coding gene Chr2:124410446-124431506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026838
 protein coding gene Chr2:129731289-129750363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024215
 protein coding gene Chr2:115418430-115434649 (-)
CAST/EiJ MGP_CASTEiJ_G0025597
 protein coding gene Chr2:124666761-124684434 (-)
CBA/J MGP_CBAJ_G0026115
 protein coding gene Chr2:134326746-134346012 (-)
DBA/2J MGP_DBA2J_G0026249
 protein coding gene Chr2:119915589-119932862 (-)
FVB/NJ MGP_FVBNJ_G0026213
 protein coding gene Chr2:118680431-118702388 (-)
LP/J MGP_LPJ_G0026354
 protein coding gene Chr2:125865809-125882200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026234
 protein coding gene Chr2:138517991-138534349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026892
 protein coding gene Chr2:123983728-124000394 (-)
PWK/PhJ MGP_PWKPhJ_G0025333
 protein coding gene Chr2:119489494-119515442 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025134
 protein coding gene Chr2:123066211-123083060 (-)
WSB/EiJ MGP_WSBEiJ_G0025670
 protein coding gene Chr2:124851968-124870643 (-)



Homology
more
  • Human Ortholog
    GATM, glycine amidinotransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATM, glycine amidinotransferase
  • Synonyms
    AGAT, AT, CCDS3, FRTS, FRTS1, RFS
  • Links
    NCBI Gene ID: 2628
    neXtProt AC: NX_P50440
    UniProt: P50440

  • Chr Location
    15q21.1; chr15:45361124-45402327 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GATM associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 4 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance obesity, reduced adipocity and improved glucose homeostasis when fed a high fat diet. Mice homozygous for an ENU-induced allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    969
  • Tissues
    148
  • cDNA Data
    169
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67092 NCBI Gene Model | MGI Sequence Detail 16805 C57BL/6J ±  kb
    transcript NM_025961 RefSeq | MGI Sequence Detail 2357 ZRU/MplStud  
    polypeptide Q9D964 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      cDNA 169
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138882
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:333911 Yu L, et al., Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment. Front Immunol. 2022;13:937331
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory