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Tnfaip8l1 Gene Detail
Summary
  • Symbol
    Tnfaip8l1
  • Name
    tumor necrosis factor, alpha-induced protein 8-like 1
  • Synonyms
    2600017J23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913693
    NCBI Gene: 66443
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56469477-56480955 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.19 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913693
 protein coding gene Chr17:56469439-56491249 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023916
 protein coding gene Chr17:57815869-57828499 (+)
A/J MGP_AJ_G0023875
 protein coding gene Chr17:56252452-56263924 (+)
AKR/J MGP_AKRJ_G0023845
 protein coding gene Chr17:56925625-56937004 (+)
BALB/cJ MGP_BALBcJ_G0023877
 protein coding gene Chr17:56076382-56088023 (+)
C3H/HeJ MGP_C3HHeJ_G0023640
 protein coding gene Chr17:57637499-57648956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024321
 protein coding gene Chr17:60094568-60105972 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021768
 protein coding gene Chr17:52750056-52761404 (+)
CAST/EiJ MGP_CASTEiJ_G0023123
 protein coding gene Chr17:57948153-57959588 (+)
CBA/J MGP_CBAJ_G0023617
 protein coding gene Chr17:62395005-62406752 (+)
DBA/2J MGP_DBA2J_G0023745
 protein coding gene Chr17:54967992-54979847 (+)
FVB/NJ MGP_FVBNJ_G0023711
 protein coding gene Chr17:54491179-54502636 (+)
LP/J MGP_LPJ_G0023825
 protein coding gene Chr17:58516151-58527872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023738
 protein coding gene Chr17:61944743-61956139 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024366
 protein coding gene Chr17:57301379-57315889 (+)
PWK/PhJ MGP_PWKPhJ_G0022868
 protein coding gene Chr17:54315471-54327977 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022680
 protein coding gene Chr17:54067699-54083377 (+)
WSB/EiJ MGP_WSBEiJ_G0023187
 protein coding gene Chr17:57914017-57926711 (+)



Homology
more
  • Human Ortholog
    TNFAIP8L1, TNF alpha induced protein 8 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFAIP8L1, TNF alpha induced protein 8 like 1
  • Synonyms
    TIPE1
  • Links
    NCBI Gene ID: 126282
    neXtProt AC: NX_Q8WVP5
    UniProt: Q8WVP5

  • Chr Location
    19p13.3; chr19:4639516-4655568 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044469 Ensembl Gene Model | MGI Sequence Detail 11479 C57BL/6J ±  kb
    transcript ENSMUST00000077788 Ensembl | MGI Sequence Detail 2379 Not Applicable  
    polypeptide ENSMUSP00000076961 Ensembl | MGI Sequence Detail 186 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016477 tumor necrosis factor alpha-induced protein 8-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR008477 Tumor necrosis factor alpha-induced protein 8-like
      IPR038355 Tumor necrosis factor alpha-induced protein 8-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342074 Lou Y, et al., Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation. J Immunol. 2023 Sep 1;211(5):874-884
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory