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Sar1b Gene Detail
Summary
  • Symbol
    Sar1b
  • Name
    secretion associated Ras related GTPase 1B
  • Synonyms
    2310075M17Rik, 2900019I22Rik, Sara2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913647
    NCBI Gene: 66397
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:51654514-51682752 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913647
 protein coding gene Chr11:51654490-51682780 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018276
 protein coding gene Chr11:51032075-51061541 (+)
A/J MGP_AJ_G0018245
 protein coding gene Chr11:49102033-49130057 (+)
AKR/J MGP_AKRJ_G0018215
 protein coding gene Chr11:50644556-50675528 (+)
BALB/cJ MGP_BALBcJ_G0018216
 protein coding gene Chr11:49401384-49430315 (+)
C3H/HeJ MGP_C3HHeJ_G0018027
 protein coding gene Chr11:50676788-50705204 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018666
 protein coding gene Chr11:52569689-52598679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016318
 protein coding gene Chr11:46659274-46686017 (+)
CAST/EiJ MGP_CASTEiJ_G0017591
 protein coding gene Chr11:50672305-50702595 (+)
CBA/J MGP_CBAJ_G0018002
 protein coding gene Chr11:55039449-55067632 (+)
DBA/2J MGP_DBA2J_G0018109
 protein coding gene Chr11:48805166-48834151 (+)
FVB/NJ MGP_FVBNJ_G0018104
 protein coding gene Chr11:48523535-48554871 (+)
LP/J MGP_LPJ_G0018185
 protein coding gene Chr11:51444380-51472843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018127
 protein coding gene Chr11:56443242-56478813 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018709
 protein coding gene Chr11:50747526-50775009 (+)
PWK/PhJ MGP_PWKPhJ_G0017367
 protein coding gene Chr11:49329650-49357516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017162
 protein coding gene Chr11:50479111-50510003 (+)
WSB/EiJ MGP_WSBEiJ_G0017639
 protein coding gene Chr11:50388241-50417391 (+)



Homology
more
  • Human Ortholog
    SAR1B, secretion associated Ras related GTPase 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAR1B, secretion associated Ras related GTPase 1B
  • Synonyms
    ANDD, CMRD, GTBPB, SARA2
  • Links
    NCBI Gene ID: 51128
    neXtProt AC: NX_Q9Y6B6
    UniProt: Q9Y6B6

  • Chr Location
    5q31.1; chr5:134601149-134649271 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sar1b mouse models; 1 with human SAR1B associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show late-gestational lethality. Heterozygous mice exhibit lower triglyceride, total cholesterol, and HDL cholesterol levels, fat malabsorption, and reduced chylomicron secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    12
  • cDNA Data
    131
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020386 Ensembl Gene Model | MGI Sequence Detail 28239 C57BL/6J ±  kb
    transcript ENSMUST00000020653 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    polypeptide ENSMUSP00000020653 Ensembl | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 131

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920195
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:342001 Wang X, et al., Manganese regulation of COPII condensation controls circulating lipid homeostasis. Nat Cell Biol. 2023 Oct 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory