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Mymk Gene Detail
Summary
  • Symbol
    Mymk
  • Name
    myomaker, myoblast fusion factor
  • Synonyms
    1110002H13Rik, Tmem8c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913389
    NCBI Gene: 66139
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26951648-26962173 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913389
 protein coding gene Chr2:26951648-26962191 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025508
 protein coding gene Chr2:25032309-25043263 (-)
A/J MGP_AJ_G0025485
 protein coding gene Chr2:24085385-24095596 (-)
AKR/J MGP_AKRJ_G0025455
 protein coding gene Chr2:24877262-24889515 (-)
BALB/cJ MGP_BALBcJ_G0025481
 protein coding gene Chr2:24205181-24215845 (-)
C3H/HeJ MGP_C3HHeJ_G0025242
 protein coding gene Chr2:24815354-24826514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025925
 protein coding gene Chr2:25884967-25896313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023336
 protein coding gene Chr2:22922820-22932553 (-)
CAST/EiJ MGP_CASTEiJ_G0024705
 protein coding gene Chr2:24693034-24703765 (-)
CBA/J MGP_CBAJ_G0025220
 protein coding gene Chr2:26780940-26793361 (-)
DBA/2J MGP_DBA2J_G0025353
 protein coding gene Chr2:23903734-23916849 (-)
FVB/NJ MGP_FVBNJ_G0025315
 protein coding gene Chr2:23664361-23674843 (-)
LP/J MGP_LPJ_G0025439
 protein coding gene Chr2:24977376-24988941 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025346
 protein coding gene Chr2:26824853-26837234 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025984
 protein coding gene Chr2:24817229-24826968 (-)
PWK/PhJ MGP_PWKPhJ_G0024453
 protein coding gene Chr2:23698271-23708340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024253
 protein coding gene Chr2:24962047-24971919 (-)
WSB/EiJ MGP_WSBEiJ_G0024774
 protein coding gene Chr2:24929642-24940901 (-)



Homology
more
  • Human Ortholog
    MYMK, myomaker, myoblast fusion factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYMK, myomaker, myoblast fusion factor
  • Synonyms
    MYOMAKER, TMEM226, TMEM8C
  • Links
    NCBI Gene ID: 389827
    neXtProt AC: NX_A6NI61
    UniProt: A6NI61

  • Chr Location
    9q34.2; chr9:133514586-133528612 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYMK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early postnatal lethality, paralysis, kyphosis and defective myoblast fusion and survival leading to the absence of differentiated muscle in the trunk, limb and head.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    45
  • cDNA Data
    41
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66139 NCBI Gene Model | MGI Sequence Detail 10526 C57BL/6J ±  kb
    transcript NM_025376 RefSeq | MGI Sequence Detail 1401 C57BL/6  
    polypeptide Q9D1N4 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 41
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138840
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338268 Dos Santos M, et al., Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution. Nat Commun. 2023 Jul 19;14(1):4333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory