About   Help   FAQ
Kcnmb4 Gene Detail
Summary
  • Symbol
    Kcnmb4
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 4
  • Synonyms
    2900045G12Rik, Slowpoke beta 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913272
    NCBI Gene: 58802
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116253766-116309783 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 64.73 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    493 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913272
protein coding gene Chr10:116251951-116309787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017745
protein coding gene Chr10:119191261-119252694 (-)
A/J MGP_AJ_G0017721
protein coding gene Chr10:114607822-114665822 (-)
AKR/J MGP_AKRJ_G0017683
protein coding gene Chr10:117929912-117987136 (-)
BALB/cJ MGP_BALBcJ_G0017684
protein coding gene Chr10:115008474-115067702 (-)
C3H/HeJ MGP_C3HHeJ_G0017509
protein coding gene Chr10:118154992-118221420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018141
protein coding gene Chr10:123336402-123397224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015821
protein coding gene Chr10:109211066-109267318 (-)
CAST/EiJ MGP_CASTEiJ_G0017071
protein coding gene Chr10:118431177-118499838 (-)
CBA/J MGP_CBAJ_G0017478
protein coding gene Chr10:128158506-128227862 (-)
DBA/2J MGP_DBA2J_G0017583
protein coding gene Chr10:113749397-113806076 (-)
FVB/NJ MGP_FVBNJ_G0017578
protein coding gene Chr10:112704216-112761579 (-)
LP/J MGP_LPJ_G0017658
protein coding gene Chr10:119775775-119837160 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017607
protein coding gene Chr10:131064537-131126345 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018179
protein coding gene Chr10:117995064-118057264 (-)
PWK/PhJ MGP_PWKPhJ_G0016853
protein coding gene Chr10:113834330-113892631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016643
protein coding gene Chr10:116802869-116865433 (-)
WSB/EiJ MGP_WSBEiJ_G0017131
protein coding gene Chr10:118174873-118233580 (-)



Homology
more
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
  • Links
    NCBI Gene ID: 27345
    neXtProt AC: NX_Q86W47
    UniProt: Q86W47

  • Chr Location
    12q15; chr12:70366290-70434292 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054934 Ensembl Gene Model | MGI Sequence Detail 56018 C57BL/6J ±  kb
    transcript ENSMUST00000068233 Ensembl | MGI Sequence Detail 1367 Not Applicable  
    polypeptide ENSMUSP00000065384 Ensembl | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009269 calcium-activated potassium channel subunit beta-4
    • InterPro Domains
      IPR003930 Potassium channel, calcium-activated, BK, beta subunit
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920173
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:327338 Sartoretti MM, et al., Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling. Development. 2022 Aug 1;149(15):dev200750

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory