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Cldn10 Gene Detail
Summary
  • Symbol
    Cldn10
  • Name
    claudin 10
  • Synonyms
    6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913101
    NCBI Gene: 58187
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:119025283-119111937 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 62.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913101
protein coding gene Chr14:119025283-119112901 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021651
protein coding gene Chr14:116400899-116492190 (+)
A/J MGP_AJ_G0021611
protein coding gene Chr14:111957772-112043261 (+)
AKR/J MGP_AKRJ_G0021587
protein coding gene Chr14:115578693-115668112 (+)
BALB/cJ MGP_BALBcJ_G0021617
protein coding gene Chr14:112498216-112586166 (+)
C3H/HeJ MGP_C3HHeJ_G0021395
protein coding gene Chr14:115474397-115565631 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022057
protein coding gene Chr14:120918099-121012650 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019595
protein coding gene Chr14:107991193-108077554 (+)
CAST/EiJ MGP_CASTEiJ_G0020910
protein coding gene Chr14:113309680-113427036 (+)
CBA/J MGP_CBAJ_G0021363
protein coding gene Chr14:125539429-125632536 (+)
DBA/2J MGP_DBA2J_G0021486
protein coding gene Chr14:111870807-111957794 (+)
FVB/NJ MGP_FVBNJ_G0021464
protein coding gene Chr14:110194200-110282100 (+)
LP/J MGP_LPJ_G0021554
protein coding gene Chr14:117431395-117527100 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021491
protein coding gene Chr14:130600634-130707170 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022080
protein coding gene Chr14:115062399-115157390 (+)
PWK/PhJ MGP_PWKPhJ_G0020654
protein coding gene Chr14:108881439-108972974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020492
protein coding gene Chr14:111309915-111405344 (+)
WSB/EiJ MGP_WSBEiJ_G0020966
protein coding gene Chr14:115844310-115938586 (+)



Homology
more
  • Human Ortholog
    CLDN10, claudin 10
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN10, claudin 10
  • Synonyms
    CPETRL3, HELIX, OSPL, OSP-L
  • Links
    NCBI Gene ID: 9071
    neXtProt AC: NX_P78369
    UniProt: P78369

  • Chr Location
    13q32.1; chr13:95433604-95579759 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking expression of this gene in the thick ascending limb of renal tubules display nephrocalcinosis, hypermagnesemia, and abnormalities in renal reabsorbtion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58187 NCBI Gene Model | MGI Sequence Detail 86655 C57BL/6J ±  kb
    transcript NM_023878 RefSeq | MGI Sequence Detail 1200 ZRU/MplStud  
    polypeptide Q9Z0S6 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289167, MGI:1925138, MGI:3696570
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 21
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
    • Latest
      J:341713 Aure MH, et al., FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation. Nat Commun. 2023 Oct 14;14(1):6485

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory