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Pigb Gene Detail
Summary
  • Symbol
    Pigb
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891825
    NCBI Gene: 55981
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72920639-72946973 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891825
 protein coding gene Chr9:72914701-72947660 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035024
 protein coding gene Chr9:73213887-73249359 (-)
A/J MGP_AJ_G0035005
 protein coding gene Chr9:70652213-70685445 (-)
AKR/J MGP_AKRJ_G0034934
 protein coding gene Chr9:72345357-72379319 (-)
BALB/cJ MGP_BALBcJ_G0034997
 protein coding gene Chr9:70359584-70392442 (-)
C3H/HeJ MGP_C3HHeJ_G0034706
 protein coding gene Chr9:72838847-72872464 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035516
 protein coding gene Chr9:75135488-75172587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032427
 protein coding gene Chr9:70122818-70154434 (-)
CAST/EiJ MGP_CASTEiJ_G0034028
 protein coding gene Chr9:73177158-73213801 (-)
CBA/J MGP_CBAJ_G0034679
 protein coding gene Chr9:77750764-77783518 (-)
DBA/2J MGP_DBA2J_G0034838
 protein coding gene Chr9:70369012-70402319 (-)
FVB/NJ MGP_FVBNJ_G0034780
 protein coding gene Chr9:69678312-69712049 (-)
LP/J MGP_LPJ_G0034919
 protein coding gene Chr9:73432995-73467870 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034821
 protein coding gene Chr9:78833559-78868482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035538
 protein coding gene Chr9:72500344-72533052 (-)
PWK/PhJ MGP_PWKPhJ_G0033732
 protein coding gene Chr9:70646042-70679784 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033565
 protein coding gene Chr9:72785133-72819743 (-)
WSB/EiJ MGP_WSBEiJ_G0034140
 protein coding gene Chr9:72434175-72468381 (-)



Homology
more
  • Human Ortholog
    PIGB, phosphatidylinositol glycan anchor biosynthesis class B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGB, phosphatidylinositol glycan anchor biosynthesis class B
  • Synonyms
    DEE80, EIEE80, GPI-MT-III, PIG-B
  • Links
    NCBI Gene ID: 9488
    neXtProt AC: NX_Q92521
    UniProt: Q92521

  • Chr Location
    15q21.3; chr15:55318960-55355648 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIGB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    7
  • Targeted
    2
  • Genomic Mutations
    1 involving Pigb
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    22 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 55981 NCBI Gene Model | MGI Sequence Detail 26335 C57BL/6J ±  kb
transcript NM_018889 RefSeq | MGI Sequence Detail 4490 C57BL/6  
polypeptide Q9JJQ0 UniProt | EBI | MGI Sequence Detail 542 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:64826 Takahashi M, et al., PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. EMBO J. 1996 Aug 15;15(16):4254-61
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory