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Hbs1l Gene Detail
Summary
  • Symbol
    Hbs1l
  • Name
    Hbs1-like (S. cerevisiae)
  • Synonyms
    2810035F15Rik, eRFS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891704
    NCBI Gene: 56422
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:21171876-21244788 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891704
 protein coding gene Chr10:21171876-21244797 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017059
 protein coding gene Chr10:19092622-19168417 (+)
A/J MGP_AJ_G0017037
 protein coding gene Chr10:18358794-18434721 (+)
AKR/J MGP_AKRJ_G0017001
 protein coding gene Chr10:18689924-18770076 (+)
BALB/cJ MGP_BALBcJ_G0016995
 protein coding gene Chr10:18422907-18500898 (+)
C3H/HeJ MGP_C3HHeJ_G0016820
 protein coding gene Chr10:19012531-19089292 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017457
 protein coding gene Chr10:19578665-19658788 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015162
 protein coding gene Chr10:17328728-17401039 (+)
CAST/EiJ MGP_CASTEiJ_G0016402
 protein coding gene Chr10:18933745-19009481 (+)
CBA/J MGP_CBAJ_G0016792
 protein coding gene Chr10:20481169-20570576 (+)
DBA/2J MGP_DBA2J_G0016900
 protein coding gene Chr10:18238188-18312206 (+)
FVB/NJ MGP_FVBNJ_G0016895
 protein coding gene Chr10:17979464-18054759 (+)
LP/J MGP_LPJ_G0016975
 protein coding gene Chr10:18888695-18964045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016925
 protein coding gene Chr10:20673038-20759158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017495
 protein coding gene Chr10:18675038-18752912 (+)
PWK/PhJ MGP_PWKPhJ_G0016187
 protein coding gene Chr10:18144642-18223727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015970
 protein coding gene Chr10:18845940-18920487 (+)
WSB/EiJ MGP_WSBEiJ_G0016464
 protein coding gene Chr10:18770978-18848026 (+)



Homology
more
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBS1L, HBS1 like translational GTPase
  • Synonyms
    EF-1a, eRF3c, ERFS, HBS1, HSPC276
  • Links
    NCBI Gene ID: 10767
    neXtProt AC: NX_Q9Y450
    UniProt: Q9Y450

  • Chr Location
    6q23.3; chr6:134960378-135103056 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HBS1L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 4 alleles in 7 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit decreased body weight, facial dysmorphism with depressed nasal and zygomatic bones, dental asymmetry, malocclusion, vertebral defects, male infertility, and abnormal retinal pigmentation. Mice homozygous for a null allele die prior to E6.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    10
  • cDNA Data
    177
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56422 NCBI Gene Model | MGI Sequence Detail 72913 C57BL/6J ±  kb
    transcript NM_001145209 RefSeq | MGI Sequence Detail 5021 C57BL/6  
    polypeptide Q69ZS7 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008465 HBS1-like protein
      (term hierarchy)
    • PDB
      1UFZ
    • EC
      3.6.5.-
    • InterPro Domains
      IPR015033 HBS1-like protein, N-terminal
      IPR037189 HBS1-like protein, N-terminal domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000795 Translational (tr)-type GTP-binding domain
      IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
      IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
      IPR004161 Translation elongation factor EFTu-like, domain 2
      IPR009000 Translation protein, beta-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 178
      cDNA 177
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914465, MGI:2143582
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory