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Cemip2 Gene Detail
Summary
  • Symbol
    Cemip2
  • Name
    cell migration inducing hyaluronidase 2
  • Synonyms
    3110012M15Rik, mKIAA1412, Tmem2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890373
    NCBI Gene: 83921
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:21755706-21835724 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 15.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1316 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890373
 protein coding gene Chr19:21755704-21835724 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024981
 protein coding gene Chr19:19848371-19929585 (+)
A/J MGP_AJ_G0024958
 protein coding gene Chr19:18760680-18840332 (+)
AKR/J MGP_AKRJ_G0024928
 protein coding gene Chr19:19467272-19548246 (+)
BALB/cJ MGP_BALBcJ_G0024957
 protein coding gene Chr19:18766694-18846951 (+)
C3H/HeJ MGP_C3HHeJ_G0024715
 protein coding gene Chr19:19421158-19502138 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025399
 protein coding gene Chr19:20507648-20592522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022818
 protein coding gene Chr19:18972282-19050273 (+)
CAST/EiJ MGP_CASTEiJ_G0024183
 protein coding gene Chr19:19124207-19204602 (+)
CBA/J MGP_CBAJ_G0024693
 protein coding gene Chr19:21341055-21420446 (+)
DBA/2J MGP_DBA2J_G0024825
 protein coding gene Chr19:18769134-18849502 (+)
FVB/NJ MGP_FVBNJ_G0024786
 protein coding gene Chr19:18624892-18705296 (+)
LP/J MGP_LPJ_G0024909
 protein coding gene Chr19:19806000-19888044 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024813
 protein coding gene Chr19:21472901-21558158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025454
 protein coding gene Chr19:19420405-19504641 (+)
PWK/PhJ MGP_PWKPhJ_G0023932
 protein coding gene Chr19:18322357-18407780 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023737
 protein coding gene Chr19:18701243-18785172 (+)
WSB/EiJ MGP_WSBEiJ_G0024251
 protein coding gene Chr19:19500518-19584732 (+)



Homology
more
  • Human Ortholog
    CEMIP2, cell migration inducing hyaluronidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEMIP2, cell migration inducing hyaluronidase 2
  • Synonyms
    TMEM2
  • Links
    NCBI Gene ID: 23670
    neXtProt AC: NX_Q9UHN6
    UniProt: Q9UHN6

  • Chr Location
    9q21.13; chr9:71683366-71816690 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for loss of expression display accumulation and impaired degradation of hyaluronan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    149
  • cDNA Data
    160
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024754 Ensembl Gene Model | MGI Sequence Detail 80019 C57BL/6J ±  kb
    transcript ENSMUST00000025663 Ensembl | MGI Sequence Detail 6602 Not Applicable  
    polypeptide ENSMUSP00000025663 Ensembl | MGI Sequence Detail 1383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 166
      cDNA 160
      Primer pair 2
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920320
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:68964 Scott DA, et al., Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Gene. 2000 Apr 4;246(1-2):265-74
    • Latest
      J:341326 Nag P, et al., Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J Dent Res. 2023 Sep;102(10):1162-1171
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory