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Cd59b Gene Detail
Summary
  • Symbol
    Cd59b
  • Name
    CD59b antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888996
    NCBI Gene: 333883
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103900127-103920619 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888996
 protein coding gene Chr2:103896142-103921534 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026214
 protein coding gene Chr2:106112087-106173935 (+)
A/J MGP_AJ_G0026174
 protein coding gene Chr2:101715859-101759324 (+)
AKR/J MGP_AKRJ_G0026153
 protein coding gene Chr2:104469784-104480621 (+)
BALB/cJ MGP_BALBcJ_G0026183
 protein coding gene Chr2:101993681-102010159 (+)
C3H/HeJ MGP_C3HHeJ_G0025934
 protein coding gene Chr2:104796387-104812323 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026634
 protein coding gene Chr2:109629919-109653944 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0025398
 protein coding gene Chr2:105272742-105315903 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0026049
 protein coding gene Chr2:101261071-101283963 (+)
FVB/NJ MGP_FVBNJ_G0026011
 protein coding gene Chr2:100255845-100270796 (+)
LP/J MGP_LPJ_G0026152
 protein coding gene Chr2:106235054-106275754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026036
 protein coding gene Chr2:117267863-117284831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026688
 protein coding gene Chr2:104686469-104735374 (+)
PWK/PhJ MGP_PWKPhJ_G0025133
 protein coding gene Chr2:100775740-100845592 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024933
 protein coding gene Chr2:103880528-103931268 (+)
WSB/EiJ MGP_WSBEiJ_G0025465
 protein coding gene Chr2:105395445-105426313 (+)



Homology
more
  • Human Ortholog
    CD59, CD59 molecule (CD59 blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD59, CD59 molecule (CD59 blood group)
  • Synonyms
    16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF20, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
  • Links
    NCBI Gene ID: 966
    neXtProt AC: NX_P13987
    UniProt: P13987

  • Chr Location
    11p13; chr11:33703010-33736479 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CD59 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation develop a severe hemolytic anemia and progressive male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 333883 NCBI Gene Model | MGI Sequence Detail 20493 C57BL/6J ±  kb
    transcript NM_001368215 RefSeq | MGI Sequence Detail 706 C57BL/6  
    polypeptide P58019 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 8
      Primer pair 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:180268 Zhang J, et al., The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011 Dec;179(6):2876-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory