Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camk4tm1Tch
Name:	calcium/calmodulin-dependent protein kinase IV; targeted mutation 1, Talal A Chatila
MGI ID:	MGI:1888972
Synonyms:	Camk4-, CaMKIV/Gr KO
Gene:	Camk4  Location: Chr18:33067984-33324281 bp, + strand  Genetic Position: Chr18, 18.15 cM
Alliance:	Camk4tm1Tch page

Germline Transmission:	Earliest citation of germline transmission: J:64210
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The replacement of the third exon, which encodes the ATP binding site in the catalytic domain of the kinase, with a neomycin resistance gene rendered the enzyme catalytically inactive and prone to degradation. (J:64210) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camk4 Mutation:	37 strains or lines available

Original:	J:64210 Ho N, et al., Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000 Sep 1;20(17):6459-72
All:	19 reference(s)