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H1f6 Gene Detail
Summary
  • Symbol
    H1f6
  • Name
    H1.6 linker histone, cluster member
  • Synonyms
    H1ft, H1t, Hist1h1t
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888530
    NCBI Gene: 107970
  • Member of
    Hist1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23879794-23880528 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.88 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888530
 protein coding gene Chr13:23879794-23880708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020357
 protein coding gene Chr13:21131256-21131981 (+)
A/J MGP_AJ_G0020308
 protein coding gene Chr13:20743040-20743765 (+)
AKR/J MGP_AKRJ_G0020288
 protein coding gene Chr13:20998120-20998845 (+)
BALB/cJ MGP_BALBcJ_G0020304
 protein coding gene Chr13:20735286-20736011 (+)
C3H/HeJ MGP_C3HHeJ_G0020109
 protein coding gene Chr13:21065216-21065941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020742
 protein coding gene Chr13:21908985-21909713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018328
 protein coding gene Chr13:19528865-19529593 (+)
CAST/EiJ MGP_CASTEiJ_G0019626
 protein coding gene Chr13:20749901-20750626 (+)
CBA/J MGP_CBAJ_G0020060
 protein coding gene Chr13:22761881-22762606 (+)
DBA/2J MGP_DBA2J_G0020188
 protein coding gene Chr13:20274870-20275595 (+)
FVB/NJ MGP_FVBNJ_G0020172
 protein coding gene Chr13:19927509-19928234 (+)
LP/J MGP_LPJ_G0020262
 protein coding gene Chr13:21441757-21442482 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020200
 protein coding gene Chr13:23058397-23059122 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020782
 protein coding gene Chr13:20847363-20848088 (+)
PWK/PhJ MGP_PWKPhJ_G0019380
 protein coding gene Chr13:20301997-20302722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019196
 protein coding gene Chr13:19643749-19644474 (+)
WSB/EiJ MGP_WSBEiJ_G0019684
 protein coding gene Chr13:20990196-20990924 (+)



Homology
more
  • Human Ortholog
    H1-6, H1.6 linker histone, cluster member
  • Vertebrate Orthologs
    17
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H1-6, H1.6 linker histone, cluster member
  • Synonyms
    dJ221C16.2, H1.6, H1FT, H1t, HIST1H1T
  • Links
    NCBI Gene ID: 3010
    neXtProt AC: NX_P22492
    UniProt: P22492

  • Chr Location
    6p22.2; chr6:26107412-26108135 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    14 phenotype references
Homozygous null mice develop normally and exhibit normal testicular morphology, spermatogenesis and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    16
  • cDNA Data
    4
  • Literature Summary
    22
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 107970 NCBI Gene Model | MGI Sequence Detail 735 C57BL/6J ±  kb
transcript NM_010377 RefSeq | MGI Sequence Detail 735 C57BL/6  
polypeptide Q07133 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 3
    cDNA 4
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 67
    Developmental Gene Expression 22
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:333262 Feng S, et al., hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory