Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Scarb1tm1Kri Name: scavenger receptor class B, member 1; targeted mutation 1, Monty Krieger MGI ID: MGI:1888384 Synonyms: srb1-, Sr-b1-, srbI-, SR-BI, SR-BI-, SR-BI KO Gene: Scarb1  Location: Chr5:125354151-125418158 bp, - strand  Genetic Position: Chr5, 64.11 cM Alliance: Scarb1tm1Kri page

Apoetm1Unc/Apoetm1Unc Scarb1tm1Kri/Scarb1tm1Kri mice develop occlusive, atherosclerotic coronary artery disease Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:44187
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette. (J:44187) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scarb1 Mutation:	52 strains or lines available

Original:	J:44187 Rigotti A, et al., A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12610-5
All:	128 reference(s)