About   Help   FAQ
Hgstm1Sor
Targeted Allele Detail
Summary
Symbol: Hgstm1Sor
Name: HGF-regulated tyrosine kinase substrate; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1861937
Synonyms: Hrs-
Gene: Hgs  Location: Chr11:120358461-120374805 bp, + strand  Genetic Position: Chr11, 84.16 cM
Alliance: Hgstm1Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55580
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 2.1 kb segment of the gene, which included exons 2, 3, and 4, encompassing the amino terminal region of the protein. In addition, the insertion produced a frameshift of exons 1 and 5. (J:55580)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hgs Mutation:  38 strains or lines available
References
Original:  J:55580 Komada M, et al., Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999 Jun 1;13(11):1475-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory