Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dab1tm1Cpr
Name:	disabled 1; targeted mutation 1, Jonathan A Cooper
MGI ID:	MGI:1861918
Synonyms:	Dab1-, Dab1 ko, mdab1-1
Gene:	Dab1  Location: Chr4:103476556-104602041 bp, + strand  Genetic Position: Chr4, 47.79 cM
Alliance:	Dab1tm1Cpr page

Germline Transmission:	Earliest citation of germline transmission: J:43647
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing sequences encoding the first 47 amino acids of the PTB domain. Western blot analysis on brain lysates derived from homozygous mice demonstrated the absence of the protein. (J:43647)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	46 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dab1 Mutation:	77 strains or lines available

Original:	J:43647 Howell BW, et al., Neuronal position in the developing brain is regulated by mouse disabled-1 [see comments]. Nature. 1997 Oct 16;389(6652):733-7
All:	37 reference(s)