Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cux1tm1Ejn
Name:	cut-like homeobox 1; targeted mutation 1, Ellis J Neufeld
MGI ID:	MGI:1861916
Synonyms:	deltaCR1
Gene:	Cux1  Location: Chr5:136276989-136596344 bp, - strand  Genetic Position: Chr5, 75.96 cM
Alliance:	Cux1tm1Ejn page

Germline Transmission:	Earliest citation of germline transmission: J:49157
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 10 and 11. Western blot analysis on spleen and thymus extracts of homozygous mice demonstrated that a mutant protein that lacked cut domain 1, but retains DNA binding activity, was produced from this allele. (J:49157)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cux1 Mutation:	111 strains or lines available

Original:	J:49157 Tufarelli C, et al., Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev Biol. 1998 Aug 1;200(1):69-81
All:	4 reference(s)