Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1tm2Ts
Name:	insulin-like growth factor 1; targeted mutation 2, Timothy Stewart
MGI ID:	MGI:1861704
Synonyms:	IGF-Im, Midi allele
Gene:	Igf1  Location: Chr10:87694127-87772904 bp, + strand  Genetic Position: Chr10, 43.7 cM
Alliance:	Igf1tm2Ts page

Germline Transmission:	Earliest citation of germline transmission: J:37969
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: Hypomorph. In this allele, a site specific insertion of the entire targeting vector occurred instead of homologous recombination. The construct interrupted exon 3 with a neomycin cassette, with a thymidine kinase gene and vector sequences inserted 5' of the endogenous exon 3. RT-PCR analysis demonstrated that a reduced amount of normal transcript was produced from this allele as well as a mutant transcript, and a low, but detectable level of the protein was present in sera of homozygous mice. (J:37969)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:	27 strains or lines available

Original:	J:37969 Lembo G, et al., Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest. 1996 Dec 1;98(11):2648-55
All:	5 reference(s)