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Tnftm1Jods
Targeted Allele Detail
Summary
Symbol: Tnftm1Jods
Name: tumor necrosis factor; targeted mutation 1, Johnathon D Sedgwick
MGI ID: MGI:1860953
Synonyms: TNF-, TNF -, TNFalpha-, TNF-KO
Gene: Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance: Tnftm1Jods page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43602
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details905 base pairs, encompassing exons 2, 3, and a portion of exon 4, were replaced with a neomycin selection cassette. RT-PCR confirmed the absence of transcript in homozygous mutant mice. (J:43602)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tnftm1Jods
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  46 strains or lines available
Notes
ES cell lines = BL/6-III and Bruce 4
References
Original:  J:43602 Korner H, et al., Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997 Oct;27(10):2600-9
All:  88 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory