Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Adrb3tm1Lowl
Name:	adrenergic receptor, beta 3; targeted mutation 1, Bradford B Lowell
MGI ID:	MGI:1860610
Synonyms:	beta3-AR -
Gene:	Adrb3  Location: Chr8:27715804-27720833 bp, - strand  Genetic Position: Chr8, 15.94 cM, cytoband A2-A4
Alliance:	Adrb3tm1Lowl page

Germline Transmission:	Earliest citation of germline transmission: J:30060
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	FVB/N

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 306bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette. An RNase protection assay demonstrated that the encoded transcript was not detectable in brown adipose tissue of homozygous mice. (J:30060)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104036 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adrb3 Mutation:	32 strains or lines available

Original:	J:30060 Susulic VS, et al., Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 8;270(49):29483-92
All:	60 reference(s)