Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrbtm1Few
Name:	thyroid hormone receptor beta; targeted mutation 1, Fredric E Wondisford
MGI ID:	MGI:1860353
Synonyms:	TRbeta2 null
Gene:	Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Thrbtm1Few page

Germline Transmission:	Earliest citation of germline transmission: J:56668
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette replaced the transcription site, the entire Thrb2-specific exon, and the splice donor acceptor site. RT-PCR analysis of pituitary RNA confirmed the preservation of the Thrb1 isoform, as well as the absence of the Thrb2 isoform. (J:56668)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:	39 strains or lines available

Original:	J:56668 Abel ED, et al., Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999 Aug;104(3):291-300
All:	2 reference(s)