Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apaf1tm1Her
Name:	apoptotic peptidase activating factor 1; targeted mutation 1, Joachim Herz
MGI ID:	MGI:1860245
Synonyms:	Apaf1-
Gene:	Apaf1  Location: Chr10:90825173-90918632 bp, - strand  Genetic Position: Chr10, 45.47 cM, cytoband C3-D1
Alliance:	Apaf1tm1Her page

Germline Transmission:	Earliest citation of germline transmission: J:60409
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin casette into sequences encoding the Ced 4 homology domain corresponding to amino acid 111. Insertion disrupts the reading frame of the protein. (J:60409) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apaf1 Mutation:	78 strains or lines available

Original:	J:60409 Honarpour N, et al., Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol. 2000 Feb 15;218(2):248-58
All:	13 reference(s)