Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf8tm1Mak
Name:	tumor necrosis factor receptor superfamily, member 8; targeted mutation 1, Tak Mak
MGI ID:	MGI:1860056
Synonyms:	CD30 -
Gene:	Tnfrsf8  Location: Chr4:144993707-145041734 bp, - strand  Genetic Position: Chr4, 78.17 cM
Alliance:	Tnfrsf8tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:62854
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A construct containing a neomycin resistance gene in the antisense direction was used to replace the second last (or second to last) exon. A dish binding assay indicated the absence of functional Tnfrsf8 protein on the surface of spleen cells isolated from homozygous mutant mice. (J:62854)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf8 Mutation:	42 strains or lines available

Original:	J:62854 Amakawa R, et al., Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 1996 Feb 23;84(4):551-62
All:	28 reference(s)