Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Traf6tm1Mak
Name:	TNF receptor-associated factor 6; targeted mutation 1, Tak Mak
MGI ID:	MGI:1859953
Synonyms:	TRAF6-
Gene:	Traf6  Location: Chr2:101508774-101532014 bp, + strand  Genetic Position: Chr2, 53.9 cM
Alliance:	Traf6tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:54467
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a neomycin selection cassette disrupted the exon encoding the translation initiation codon and the first 100 residues, which constitute the amino terminal portion of the zinc RING finger domain. Western blot analysis of renal immunoprecipitates and total renal lysates showed an absence of protein in homozygous mutant mice. (J:54467)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Traf6 Mutation:	31 strains or lines available

Original:	J:54467 Lomaga MA, et al., TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999 Apr 15;13(8):1015-24
All:	12 reference(s)