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Slc13a1 Gene Detail
Summary
  • Symbol
    Slc13a1
  • Name
    solute carrier family 13 (sodium/sulfate symporters), member 1
  • Synonyms
    Nas1, NaSi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859937
    NCBI Gene: 55961
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:24088282-24168091 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859937
 protein coding gene Chr6:24088282-24168118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030492
 protein coding gene Chr6:21655232-21740905 (-)
A/J MGP_AJ_G0030465
 protein coding gene Chr6:20737981-20817286 (-)
AKR/J MGP_AKRJ_G0030392
 protein coding gene Chr6:21391226-21471151 (-)
BALB/cJ MGP_BALBcJ_G0030475
 protein coding gene Chr6:20822542-20917069 (-)
C3H/HeJ MGP_C3HHeJ_G0030188
 protein coding gene Chr6:21390422-21473016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030929
 protein coding gene Chr6:22332438-22417776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028140
 protein coding gene Chr6:19225768-19301599 (-)
CAST/EiJ MGP_CASTEiJ_G0029590
 protein coding gene Chr6:21251030-21342897 (-)
CBA/J MGP_CBAJ_G0030166
 protein coding gene Chr6:23075844-23165275 (-)
DBA/2J MGP_DBA2J_G0030310
 protein coding gene Chr6:20701693-20780545 (-)
FVB/NJ MGP_FVBNJ_G0030264
 protein coding gene Chr6:20461906-20540371 (-)
LP/J MGP_LPJ_G0030397
 protein coding gene Chr6:21781551-21864620 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030300
 protein coding gene Chr6:24987613-25077885 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030959
 protein coding gene Chr6:21347028-21431590 (-)
PWK/PhJ MGP_PWKPhJ_G0029304
 protein coding gene Chr6:20254448-20335553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029140
 protein coding gene Chr6:21060863-21155702 (-)
WSB/EiJ MGP_WSBEiJ_G0029666
 protein coding gene Chr6:21280150-21362887 (-)



Homology
more
  • Human Ortholog
    SLC13A1, solute carrier family 13 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC13A1, solute carrier family 13 member 1
  • Synonyms
    NAS1, NaSi-1
  • Links
    NCBI Gene ID: 6561
    neXtProt AC: NX_Q9BZW2
    UniProt: Q9BZW2

  • Chr Location
    7q31.32; chr7:123113531-123199972 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit hyposulfatemia, growth retardation, reduced female fertility, and spontaneous clonic seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1104
  • Tissues
    162
  • cDNA Data
    50
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029700 Ensembl Gene Model | MGI Sequence Detail 79810 C57BL/6J ±  kb
    transcript ENSMUST00000031713 Ensembl | MGI Sequence Detail 2495 Not Applicable  
    polypeptide ENSMUSP00000031713 Ensembl | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 51
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141388, MGI:2141522
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:61656 Beck L, et al., The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J Biol Chem. 2000 Apr 21;275(16):11880-90
    • Latest
      J:281175 Yorgan TA, et al., Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory