Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Trp73tm1Fmc
Name:	transformation related protein 73; targeted mutation 1, Frank McKeon
MGI ID:	MGI:1859911
Synonyms:	p73 -
Gene:	Trp73  Location: Chr4:154140706-154224332 bp, - strand  Genetic Position: Chr4, 83.79 cM
Alliance:	Trp73tm1Fmc page

Germline Transmission:	Earliest citation of germline transmission: J:60896
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5 and a portion of exon 6, encoding part of the DNA binding domain, and the neighboring intronic sequences were replaced by a neomycin gene. (J:60896)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

List all tumor models in MMHCdb carrying Trp73tm1Fmc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp73 Mutation:	42 strains or lines available

Original:	J:60896 Yang A, et al., p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000 Mar 2;404(6773):99-103
All:	45 reference(s)