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Prickle3 Gene Detail
Summary
  • Symbol
    Prickle3
  • Name
    prickle planar cell polarity protein 3
  • Synonyms
    Lmo6, Sfc16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859635
    NCBI Gene: 54630
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7523584-7534425 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859635
 protein coding gene ChrX:7523499-7534425 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035516
 protein coding gene ChrX:2268898-2279505 (+)
A/J MGP_AJ_G0035494
 protein coding gene ChrX:2232197-2243430 (+)
AKR/J MGP_AKRJ_G0035427
 protein coding gene ChrX:2335354-2346252 (+)
BALB/cJ MGP_BALBcJ_G0035490
 protein coding gene ChrX:2248338-2259235 (+)
C3H/HeJ MGP_C3HHeJ_G0035198
 protein coding gene ChrX:2303035-2313827 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036014
 protein coding gene ChrX:2344959-2355573 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032889
 protein coding gene ChrX:1798283-1808917 (+)
CAST/EiJ MGP_CASTEiJ_G0034498
 protein coding gene ChrX:2203634-2216557 (+)
CBA/J MGP_CBAJ_G0035168
 protein coding gene ChrX:2464305-2482222 (+)
DBA/2J MGP_DBA2J_G0035325
 protein coding gene ChrX:2252675-2264013 (+)
FVB/NJ MGP_FVBNJ_G0035272
 protein coding gene ChrX:2214743-2225098 (+)
LP/J MGP_LPJ_G0035402
 protein coding gene ChrX:2269193-2281655 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035311
 protein coding gene ChrX:2427193-2437897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036032
 protein coding gene ChrX:2255681-2269574 (+)
PWK/PhJ MGP_PWKPhJ_G0034200
 protein coding gene ChrX:2185023-2197787 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034037
 protein coding gene ChrX:2223801-2234687 (+)
WSB/EiJ MGP_WSBEiJ_G0034621
 protein coding gene ChrX:2258257-2270028 (+)



Homology
more
  • Human Ortholog
    PRICKLE3, prickle planar cell polarity protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRICKLE3, prickle planar cell polarity protein 3
  • Synonyms
    LMO6, LOAM, LOAS, Pk3
  • Links
    NCBI Gene ID: 4007
    neXtProt AC: NX_O43900
    UniProt: O43900

  • Chr Location
    Xp11.23; chrX:49174802-49186528 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prickle3 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for a null allele exhibit Leber's hereditary optic neuropathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    60
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54630 NCBI Gene Model | MGI Sequence Detail 10842 C57BL/6J ±  kb
    transcript NR_189670 RefSeq | MGI Sequence Detail 3367 C57BL/6  
    polypeptide Q80VL3 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 5
      cDNA 19
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:62168 Means GD, et al., A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics. 2000 May 1;65(3):213-23
    • Latest
      J:300151 Yu J, et al., PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy. J Clin Invest. 2020 Sep 1;130(9):4935-4946
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory