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Arhgef5 Gene Detail
Summary
  • Symbol
    Arhgef5
  • Name
    Rho guanine nucleotide exchange factor 5
  • Synonyms
    2210412D05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858952
    NCBI Gene: 54324
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:43242578-43266254 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 21.15 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858952
 protein coding gene Chr6:43242516-43266254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030676
 protein coding gene Chr6:41895100-41918824 (+)
A/J MGP_AJ_G0030649
 protein coding gene Chr6:40049767-40073507 (+)
AKR/J MGP_AKRJ_G0030574
 protein coding gene Chr6:41380079-41403819 (+)
BALB/cJ MGP_BALBcJ_G0030659
 protein coding gene Chr6:40340606-40364338 (+)
C3H/HeJ MGP_C3HHeJ_G0030372
 protein coding gene Chr6:41392658-41416394 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031113
 protein coding gene Chr6:42897278-42924335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028320
 protein coding gene Chr6:37952750-37977585 (+)
CAST/EiJ MGP_CASTEiJ_G0029776
 protein coding gene Chr6:41156984-41180936 (+)
CBA/J MGP_CBAJ_G0030347
 protein coding gene Chr6:44642203-44665917 (+)
DBA/2J MGP_DBA2J_G0030496
 protein coding gene Chr6:39925778-39949492 (+)
FVB/NJ MGP_FVBNJ_G0030447
 protein coding gene Chr6:39641224-39664948 (+)
LP/J MGP_LPJ_G0030580
 protein coding gene Chr6:41862558-41886287 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030482
 protein coding gene Chr6:46965060-46988736 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031143
 protein coding gene Chr6:41319518-41343235 (+)
PWK/PhJ MGP_PWKPhJ_G0029488
 protein coding gene Chr6:39466608-39490444 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029324
 protein coding gene Chr6:40853013-40877012 (+)
WSB/EiJ MGP_WSBEiJ_G0029852
 protein coding gene Chr6:41280669-41304411 (+)



Homology
more
  • Human Ortholog
    ARHGEF5, Rho guanine nucleotide exchange factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF5, Rho guanine nucleotide exchange factor 5
  • Synonyms
    GEF5, P60, TIM, TIM1
  • Links
    NCBI Gene ID: 7984
    neXtProt AC: NX_Q12774
    UniProt: Q12774

  • Chr Location
    7q35; chr7:144355288-144380632 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased Th2 response in an ovalbumin-induced asthma model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    61
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54324 NCBI Gene Model | MGI Sequence Detail 23677 C57BL/6J ±  kb
transcript NM_133674 RefSeq | MGI Sequence Detail 5403 C57BL/6  
polypeptide E9Q7D5 UniProt | EBI | MGI Sequence Detail 1581 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 1
    cDNA 61

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919632, MGI:2141687
References
more
  • Summaries
    All 44
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
  • Latest
    J:291503 Bernadzki KM, et al., Arhgef5 Binds alpha-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity. Front Mol Neurosci. 2020;13:104
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory