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Ngef Gene Detail
Summary
  • Symbol
    Ngef
  • Name
    neuronal guanine nucleotide exchange factor
  • Synonyms
    ephexin, Tims2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858414
    NCBI Gene: 53972
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87404556-87501592 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858414
 protein coding gene Chr1:87404551-87501661 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016266
 protein coding gene Chr1:88836740-88942519 (-)
A/J MGP_AJ_G0016247
 protein coding gene Chr1:85508590-85606274 (-)
AKR/J MGP_AKRJ_G0016208
 protein coding gene Chr1:88030741-88132747 (-)
BALB/cJ MGP_BALBcJ_G0016204
 protein coding gene Chr1:85626143-85726581 (-)
C3H/HeJ MGP_C3HHeJ_G0016032
 protein coding gene Chr1:88289811-88395577 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016660
 protein coding gene Chr1:92149776-92243786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014382
 protein coding gene Chr1:79959301-80055463 (-)
CAST/EiJ MGP_CASTEiJ_G0015617
 protein coding gene Chr1:87507856-87607356 (-)
CBA/J MGP_CBAJ_G0016008
 protein coding gene Chr1:95073019-95183335 (-)
DBA/2J MGP_DBA2J_G0016111
 protein coding gene Chr1:84808389-84905581 (-)
FVB/NJ MGP_FVBNJ_G0016110
 protein coding gene Chr1:83870071-83966443 (-)
LP/J MGP_LPJ_G0016182
 protein coding gene Chr1:89898217-89991099 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016136
 protein coding gene Chr1:98351183-98456305 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016703
 protein coding gene Chr1:88142499-88244091 (-)
PWK/PhJ MGP_PWKPhJ_G0015404
 protein coding gene Chr1:84109408-84199660 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015184
 protein coding gene Chr1:87059772-87152112 (-)
WSB/EiJ MGP_WSBEiJ_G0015681
 protein coding gene Chr1:87815169-87917353 (-)



Homology
more
  • Human Ortholog
    NGEF, neuronal guanine nucleotide exchange factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NGEF, neuronal guanine nucleotide exchange factor
  • Synonyms
    ARHGEF27, EPHEXIN
  • Links
    NCBI Gene ID: 25791
    neXtProt AC: NX_Q8N5V2
    UniProt: Q8N5V2

  • Chr Location
    2q37.1; chr2:232878701-233013256 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and show no overt axonal phenotype; however, cultured retinal ganglion cells display defects in axonal outgrowth and ephrin-induced growth cone collapse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    35
  • cDNA Data
    31
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026259 Ensembl Gene Model | MGI Sequence Detail 97037 C57BL/6J ±  kb
transcript ENSMUST00000068681 Ensembl | MGI Sequence Detail 3109 Not Applicable  
polypeptide ENSMUSP00000066894 Ensembl | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 32
    Primer pair 7
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1202845
References
more
  • Summaries
    All 46
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory