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Ppm1d Gene Detail
Summary
  • Symbol
    Ppm1d
  • Name
    protein phosphatase 1D magnesium-dependent, delta isoform
  • Synonyms
    Wip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858214
    NCBI Gene: 53892
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:85202080-85237897 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858214
 protein coding gene Chr11:85202070-85237897 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018881
 protein coding gene Chr11:86806788-86849405 (+)
A/J MGP_AJ_G0018848
 protein coding gene Chr11:83475129-83516764 (+)
AKR/J MGP_AKRJ_G0018818
 protein coding gene Chr11:85973728-86016818 (+)
BALB/cJ MGP_BALBcJ_G0018821
 protein coding gene Chr11:83865599-83901080 (+)
C3H/HeJ MGP_C3HHeJ_G0018635
 protein coding gene Chr11:86005496-86045253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019273
 protein coding gene Chr11:89454864-89491095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016906
 protein coding gene Chr11:80530721-80564020 (+)
CAST/EiJ MGP_CASTEiJ_G0018190
 protein coding gene Chr11:86654467-86692676 (+)
CBA/J MGP_CBAJ_G0018606
 protein coding gene Chr11:93241324-93292110 (+)
DBA/2J MGP_DBA2J_G0018714
 protein coding gene Chr11:83052761-83089903 (+)
FVB/NJ MGP_FVBNJ_G0018703
 protein coding gene Chr11:82553606-82590521 (+)
LP/J MGP_LPJ_G0018784
 protein coding gene Chr11:87320462-87358325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018730
 protein coding gene Chr11:93373651-93414033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019313
 protein coding gene Chr11:86225106-86262478 (+)
PWK/PhJ MGP_PWKPhJ_G0017959
 protein coding gene Chr11:83827568-83865227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017751
 protein coding gene Chr11:85761832-85811696 (+)
WSB/EiJ MGP_WSBEiJ_G0018241
 protein coding gene Chr11:86068952-86112631 (+)



Homology
more
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
  • Synonyms
    IDDGIP, JDVS, PP2C-DELTA, WIP1
  • Links
    NCBI Gene ID: 8493
    neXtProt AC: NX_O15297
    UniProt: O15297

  • Chr Location
    17q23.2; chr17:60600193-60666280 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPM1D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    24
  • cDNA Data
    47
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53892 NCBI Gene Model | MGI Sequence Detail 35818 C57BL/6J ±  kb
    transcript NM_016910 RefSeq | MGI Sequence Detail 2911 ZRU/MplStud  
    polypeptide Q9QZ67 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 50
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144473
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 48
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:343530 Miller PG, et al., PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood. 2023 Dec 14;142(24):2079-2091
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory