Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ep300tm1Dli
Name:	E1A binding protein p300; targeted mutation 1, David Livingston
MGI ID:	MGI:1858020
Synonyms:	p300-
Gene:	Ep300  Location: Chr15:81470329-81536278 bp, + strand  Genetic Position: Chr15, 38.16 cM
Alliance:	Ep300tm1Dli page

Germline Transmission:	Earliest citation of germline transmission: J:47301
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons encoding the first cys/his rich domain were replaced with a neomycin selection cassette. Western blot analysis on embryonic fibroblasts derived from homozygous E10.5 embryos demonstrated that no detectable protein was expressed. (J:47301)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

List all tumor models in MMHCdb carrying Ep300tm1Dli

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:	97 strains or lines available

Original:	J:47301 Yao TP, et al., Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998 May 1;93(3):361-72
All:	8 reference(s)