Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lbptm1Buru
Name:	lipopolysaccharide binding protein; targeted mutation 1, Boston University School of Medicine
MGI ID:	MGI:1857975
Synonyms:	LBP-
Gene:	Lbp  Location: Chr2:158148413-158174772 bp, + strand  Genetic Position: Chr2, 78.72 cM
Alliance:	Lbptm1Buru page

Germline Transmission:	Earliest citation of germline transmission: J:44878
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced all of the first exon, including the translational start site, and part of the first intron. RT-PCR on liver and kidney samples from homozygous mutant mice showed very little transcript and no transcript, respectively, for the targeted gene in these organs. (J:44878)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lbp Mutation:	28 strains or lines available

Original:	J:44878 Wurfel MM, et al., Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997 Dec 15;186(12):2051-6
All:	13 reference(s)