Apex1<tm1Djc> Targeted Allele Detail MGI Mouse (MGI:1857955)

Apex1^tm1Djc
Targeted Allele Detail

Summary

Symbol:	Apex1^tm1Djc
Name:	apurinic/apyrimidinic endonuclease 1; targeted mutation 1, David J Chen
MGI ID:	MGI:1857955
Synonyms:	Ape/Ref^-
Gene:	Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
Alliance:	Apex1^tm1Djc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:50702
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Exon 2, intron 2, exon 3 and part of intron 3 were replaced by a neomycin resistance cassette. (J:50702)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Apex1 Mutation:	16 strains or lines available

Notes

Homozygous mutant embryos proceed to embryonic day 6.5 - 7 with normal morphology and can be genotyped by PCR from day 9.5 embryo stages before their lethality. Pre-implantation blastocysts are gamma ionizing radiation sensitive (J:50702).

References

Original:	J:50702 Ludwig DL, et al., A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity. Mutat Res. 1998 Oct 21;409(1):17-29
All:	5 reference(s)

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