Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmp8atm1Blh
Name:	bone morphogenetic protein 8a; targeted mutation 1, Brigid L Hogan
MGI ID:	MGI:1857953
Synonyms:	Bmp8a-, Bmp8atm1
Gene:	Bmp8a  Location: Chr4:123206438-123237045 bp, - strand  Genetic Position: Chr4, 57.42 cM
Alliance:	Bmp8atm1Blh page

Germline Transmission:	Earliest citation of germline transmission: J:46927
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An 8 kb genomic fragment containing exons 4-6 was replaced with a neomycin selection cassette. In situ hybridization experiments on spermatids in testes of homozygous male mice demonstrated that an aberrant transcript is produced from this allele, but no functional protein is predicted to be produced from this allele since the majority of the coding sequences were deleted. (J:46927)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp8a Mutation:	19 strains or lines available

Original:	J:46927 Zhao GQ, et al., Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Development. 1998 Mar;125(6):1103-12
All:	3 reference(s)