Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Apctm1Rak Name: APC, WNT signaling pathway regulator; targeted mutation 1, Raju Kucherlapati MGI ID: MGI:1857951 Synonyms: APC1638, Apc1638N, APC1638N Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM Alliance: Apctm1Rak page

Microadenoma in Mbd4tm1Wed/Mbd4tm1Wed Apctm1Rak/Apc+ gastrointestinal tract Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:20443
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 15 at a site corresponding to codon 1638. This mutation is predicted to result in a truncated protein. RT-PCR analysis detected a mutated transcript produced from this allele, but a truncated protein was not consistently detected by Western blot analysis. (J:20443)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Apctm1Rak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:20443 Fodde R, et al., A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73
All:	107 reference(s)