Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mgmttm1Mse
Name:	O-6-methylguanine-DNA methyltransferase; targeted mutation 1, Mutsuo Sekiguchi
MGI ID:	MGI:1857949
Synonyms:	Mgmt-
Gene:	Mgmt  Location: Chr7:136496343-136731995 bp, + strand  Genetic Position: Chr7, 82.07 cM
Alliance:	Mgmttm1Mse page

Germline Transmission:	Earliest citation of germline transmission: J:33696
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of part of the second exon, encoding the initiation codon, with a neomycin cassette. (J:33696)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Mgmttm1Mse

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgmt Mutation:	29 strains or lines available

Original:	J:33696 Tsuzuki T, et al., Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent. Carcinogenesis. 1996 Jun;17(6):1215-20
All:	6 reference(s)