Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	E2f1tm1Njd
Name:	E2F transcription factor 1; targeted mutation 1, Nicholas J Dyson
MGI ID:	MGI:1857944
Synonyms:	E2f1-, E2F-1-
Gene:	E2f1  Location: Chr2:154401327-154411812 bp, - strand  Genetic Position: Chr2, 76.79 cM
Alliance:	E2f1tm1Njd page

Germline Transmission:	Earliest citation of germline transmission: J:33099
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 2 and part of exon 3, encoding residues critical for cyclin and DNA binding, was replaced with a neomycin cassette in antisense orientation. Immunoprecipitation and Western blot analysis demonstrated that no protein was made in fibroblasts isolated from E12.5 homozygous embryos. (J:33099)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

List all tumor models in MMHCdb carrying E2f1tm1Njd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:	25 strains or lines available

Original:	J:33099 Yamasaki L, et al., Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996 May 17;85(4):537-48
All:	29 reference(s)