Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cftrtm1Bay
Name:	cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Baylor College of Medicine
MGI ID:	MGI:1857897
Synonyms:	cftrm1Bay
Gene:	Cftr  Location: Chr6:18170686-18322767 bp, + strand  Genetic Position: Chr6, 8.1 cM, cytoband A3
Alliance:	Cftrtm1Bay page

Germline Transmission:	Earliest citation of germline transmission: J:15244
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Duplication, Insertion   Cftrtm1Bay involves 1 genes/genome features (Cftr) View all   Mutation details: An insertion vector that contained exon 3 and a neomycin selection cassette was inserted into intron 2 of the gene. The duplication of exon 3 caused a frameshift change. (J:15244)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cftr Mutation:	97 strains or lines available

Original:	J:15244 O'Neal WK, et al., A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Hum Mol Genet. 1993 Oct;2(10):1561-9
All:	2 reference(s)