Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxb1tm3Mrc
Name:	homeobox B1; targeted mutation 3, Mario R Capecchi
MGI ID:	MGI:1857859
Synonyms:	Hoxb1BloxP
Gene:	Hoxb1  Location: Chr11:96256578-96259082 bp, + strand  Genetic Position: Chr11, 59.86 cM
Alliance:	Hoxb1tm3Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:41540
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of a 371 bp BglII fragment of exon 2 with a loxP-flanked neomycin cassette and an insertion of a 12 bp linker into exon 1. The neomycin cassette was removed via Cre-mediated recombination in the final allele. (J:41540)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	105 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb1 Mutation:	24 strains or lines available

Original:	J:41540 Rossel M, et al., Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development. 1999 Nov;126(22):5027-40
All:	2 reference(s)