Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rarbtm1Mma
Name:	retinoic acid receptor, beta; targeted mutation 1, Manuel Mark
MGI ID:	MGI:1857851
Synonyms:	RARbeta-
Gene:	Rarb  Location: Chr14:5650540-6038924 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Alliance:	Rarbtm1Mma page

Germline Transmission:	Earliest citation of germline transmission: J:43344
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette replaced exon 9 and a 5' region of exon 10, both of which encode a portion of the functionally essential ligand-binding domain common to all isoforms. Western blot analysis demonstrated an absence of functional protein in homozygous mutant embryos. RNAse protection assays of mRNA derived from homozygous mutant embryos showed that only truncated transcripts were present. (J:43344)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	155 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:	39 strains or lines available

Original:	J:43344 Ghyselinck NB, et al., Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997 Jun;41(3):425-47
All:	15 reference(s)