About   Help   FAQ
Ikbkbtm1Trk
Targeted Allele Detail
Summary
Symbol: Ikbkbtm1Trk
Name: inhibitor of kappaB kinase beta; targeted mutation 1, Tularik Inc
MGI ID: MGI:1857761
Synonyms: IKK-beta-
Gene: Ikbkb  Location: Chr8:23149228-23196605 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Alliance: Ikbkbtm1Trk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55680
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette disrupted exon 2 of the gene, which encodes the ATP binding site of the kinase domain. (J:55680)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  54 strains or lines available
References
Original:  J:55680 Tanaka M, et al., Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity. 1999 Apr;10(4):421-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory