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Lig4tm1Fwa
Targeted Allele Detail
Summary
Symbol: Lig4tm1Fwa
Name: ligase IV, DNA, ATP-dependent; targeted mutation 1, Frederick W Alt
MGI ID: MGI:1857732
Synonyms: Lig4-, LigIV-
Gene: Lig4  Location: Chr8:10020020-10027680 bp, - strand  Genetic Position: Chr8, 4.52 cM
Alliance: Lig4tm1Fwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50865
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced more than 50% of the coding sequences for the gene, removing the nucleotide sequences that encode amino acids 143 - 608 of the protein. (J:50865)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Lig4tm1Fwa
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lig4 Mutation:  44 strains or lines available
References
Original:  J:50865 Frank KM, et al., Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12;396(6707):173-7
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory